MAP-tau quantification in cell lysates
Tau proteins are required to stabilize microtubules through tubulin association. Deregulation of Tau expression, aggregation, and subsequent phosphorylation have been correlated to the onset of pathologies linked to the nervous system such as Alzheimer's and Parkinson's. The Tau aggregation assay detects human Tau aggregates rapidly in brain tissues and cell cultures. This kit is part of our Tau range, including phosphorylated Tau detection and total Tau measurement (MAP-Tau).
Triple-transgenic mice (Tau / PSEN2 / APP) were used as Alzheimer models. These mice develop an Alzheimer-like pathology that starts at 10 months old and progresses over time. The aim of this experiment was to detect differences in the quantity of Tau aggregates between 10 and 14 month-old mice, in the earlier stages of the disease. The graph shows that assay sensitivity enables clear discrimination between the early stages of the fibrillation process. These results correlate with those obtained for Tau phosphorylation.
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