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Somatomedin C (IGF-I) immunoradiometric assay kit RIA

The IGF1-RIACT kit is an immunoradiometric assay for somatomedin C (IGF-I) to explore and monitor growth disorders in children and adults.
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The IGF1-RIACT kit is an immunoradiometric assay for somatomedin C (IGF-I) to explore and monitor growth disorders in children and adults.
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In stock

Overview

Diagnosis and monitor treatment for growth-related disorders in children

Assess adult hGH deficiency

Monitor acromegaly treatment

Assess nutritional state

Benefits

  • NO INTERFERENCE WITH BINDING PROTEINS
  • NO EXTRACTION NECESSARY

Assay principle: sandwich

Two monoclonal antibodies directed against two different antigenic sites of the IGF-I molecule are used for the sandwich. The first one is adsorbed onto the tube walls. The second one, radiolabeled with iodine-125, is used as the tracer. A predilution of the samples (1/31) with an acidic solution is required to strip the carrier protein (BP). This carrier protein is then saturated by IGF-II. The use of IGF-II molecules in the assay avoids any reassociation between IGF-I and the carrier protein (IGF-BP).

Assay procedure: 2h at RT / shaking + 2h at RT / shaking.

Features

Working range: 1 – 1000 ng/mL (IRS 87/518)

Sample: serum or plasma – 25 µL - predilution required (1/31) Analytical sensitivity: 1 ng/mL

Normal values for adults

PopulationAge (years)18 - 2021 - 2324 - 2627 - 2930 - 3940 - 4950 - 5960 - 6970 - 89
nIGF-I ng/mLnIGF-I ng/mLnIGF-I ng/mLnIGF-I ng/mLnIGF-I ng/mLnIGF-I ng/mLnIGF-I ng/mLnIGF-I ng/mLnIGF-I ng/mL
Men
57
63
54
50
56
51
54
49
34
Median
317
279
251
233
209
178
159
149
132
2.5th percentile
197
173
155
143
127
107
94
87
75
97.5th percentile
486
430
389
363
329
286
262
250
231
Women
42
55
45
48
47
50
54
48
50
Median
339
310
285
264
225
184
153
131
122
2.5th percentile
169
159
150
142
126
107
90
76
67
97.5th percentile
517
476
440
410
356
297
247
209
189

For Children

PopulationNormal size children
Pubertal stageAge (years)n5th percentileMedian95th percentile
IGF-I ng/mLIGF-I ng/mLIGF-I ng/mL
Tanner I0 – 2425086143
Tanner I2 – 42451121218
Tanner I4 – 851106163250
Tanner I8 – 1038126194261
Tanner I> 1013140242496
Tanner II
20198294551
Tanner III
22238430672
Tanner IV
20312470870
Tanner V
11302451774
Population
Constitutionally small size children
Pubertal stageAge (years)n5th percentileMedian95th percentile
IGF-I ng/mLIGF-I ng/mLIGF-I ng/mL
Tanner I< 8303469145
Tanner I8 – 10194691207
Tanner I> 104985151236
Tanner II
18130166361
Tanner III
13147277462
Tanner IV
9198325442

IVD Product list 2020

Immunoassays RIA and ELISA - Catalog

Catalogue produits IVD 2020

Immuno-analyse RIA et ELISA - Catalog

Annual availability Schedule 2020

In-vitro RIA products - Availability calendar

Calendrier de mise a disposition 2020

Trousse pour radioimmunologie - Availability calendar

Certificat IGF1 / IGF1-RIACT

IGF1-RIACT - Certificat

Safety Data Sheet (DEU) IGF1 / IGF1-RIACT

IGF1-RIACT - Safety Data Sheet

Safety Data Sheet (ELL) IGF1 / IGF1-RIACT

IGF1-RIACT - Safety Data Sheet

Safety Data Sheet (ITA) IGF1 / IGF1-RIACT

IGF1-RIACT - Safety Data Sheet

Safety Data Sheet (SPA) IGF1 / IGF1-RIACT

IGF1-RIACT - Safety Data Sheet

Safety Data Sheet (ENG-GB) IGF1 / IGF1-RIACT

IGF1-RIACT - Safety Data Sheet

Safety Data Sheet (ENG-US) IGF1 / IGF1-RIACT

IGF1-RIACT - Safety Data Sheet

Safety Data Sheet (FRA-FR) IGF1 / IGF1-RIACT

IGF1-RIACT - Safety Data Sheet

Quality Control Report IGF1 / IGF1-RIACT

IGF1-RIACT Batch 224A(2h+2h) - Quality Control Report

Quality Control Report IGF1 / IGF1-RIACT

IGF1-RIACT Batch 225A(2h+2h) - Quality Control Report