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Osteocalcin immunoradiometric assay kit

Osteocalcin immunoradiometric assay kit RIA

The OSTEO-RIACT kit is a specific immunoradiometric assay of 1-49 human intact peptide 1-43 osteocalcin associated to bone disorders.

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The OSTEO-RIACT kit is a specific immunoradiometric assay of 1-49 human intact peptide 1-43 osteocalcin associated to bone disorders.

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Overview

Classify primary osteoporosis (low or high remodeling) Systematically monitor osteoporosis treatment

Associated with PTH, assess renal osteodystrophy

Evaluate osteoblastic activity for patients under prolonged corticosteroid therapy

Benefits

ACCURATE AND RELIABLE ASSAY

Assay principle: sandwich

Two monoclonal antibodies specific to osteocalcin recognizing the intact 1-49 region and 1-43 peptide are used for the sandwich. The first one is adsorbed onto the tube walls. The second one, radiolabeled with iodine-125, is used as the tracer.

One-step assay procedure: 2h at RT / shaking.

Features

Working range: 0.4 – 300 ng/mL

Sample: serum or EDTA, heparin plasma – 50 µL

Analytical sensitivity: 0.4 ng/mL

Normal values

Population	Age (years)	n	Mean ng/mL	Median ng/mL	Extreme values ng/mL
Males	20 30	48	23.8	22.0	11.3 37.0
	31 40	51	21.5	19.4	10.7 34.1
	41 50	49	20.3	19.9	5.2 34.5
	51 60	91	18.7	18.6	6.3 30.7
	61 - 70	60	19.1	19.2	8.8 29.7
Females	20 30	70	21.8	21.1	8.8 39.4
	31 40	87	17.1	16.2	7.7 31.9
	41 - 50	74	15.7	15.0	8.0 36.0