Opioid Delta, Mu and KappaR fluorescent probe
Tag-lite Opioid Delta & Kappa receptors fluorescent probe
One of the major subtypes of opioid receptors, Delta Opioid (or DOP) is predominantly expressed in the brain (dopaminergic neurons). The Delta opioid receptor is highly involved in pain, reward and addiction.
Cells expressing the DOP receptor are provided pre-labeled with Terbium, and can be used to conduct receptor binding studies on the aforementioned receptor.
Running your Delta opioid receptor binding assay using Tag-lite is as easy as it can gets. Simply dispense 10 µL of labeled cells into each well, followed by 5 µL of labeled ligand (L0005RED) and 5 µL of the compound you wish to test. Like all HTRF assays, Tag-lite assays do not require any washing steps. A diagram of the procedure to be followed is given on the right.
Examples of data obtained using Delta opioid labeled cells and their matching fluorescent ligand (L0005RED). Naltrindole was used as reference ligand. Results may vary from one HTRF® compatible reader to another.
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